Table 3 Material safety observations from input–output analysis of both synthesis routes A and B

Vanillin, solid

Skin Sens. 1

Eye Irrit. 2

Vanillin, solid

Skin Sens. 1

Eye Irrit. 2

2-Methoxyhydroquinone

Acute Tox. 4

Skin Irrit. 2

Eye Irrit. 2

STOT SE 3

Aquatic Acute 1

2-Methoxyhydroquinone

Acute Tox. 4

Skin Irrit. 2

Eye Irrit. 2

STOT SE 3

Aquatic Acute 1

Tetrahydrofuran (THF)

Flam. Liq. 2

Acute Tox. 4

Eye Irrit. 2

STOT SE 3

Carc. 2

2-Methyltetrahydrofuran (MTHF, for LCA THF)

Flam. Liq. 2

Acute Tox. 4

Skin Irrit. 2

Eye Dam. 1

Eye Irrit. 2

STOT SE 3

Sodium hydroxide (NaOH)

Skin Corr. 1A

Sodium hydroxide (NaOH)

Skin Corr. 1A

Sodium percarbonate (Na₂CO₃·1.5 H₂O₂)

Ox. Sol. 2

Acute Tox. 4

Eye Dam. 1

Toluol

Flam. Liq. 2

Repr. 2

Asp. Tox. 1

STOT SE 3

STOT RE 2 *

Skin Irrit. 2

Hydrogen peroxide (H₂O₂)

Ox. Liq. 1

Acute Tox. 4

Skin Corr. 1A

Eye Dam. 1

Acute Tox. 4

STOT SE 3

Aquatic Chronic 3

Sodium nitrate (NaNO₃)

Ox. Sol. 2

Acute Tox. 4

Eye Irrit. 2

Carbon dioxide (CO₂)

–

Carbon dioxide (CO₂)

–

Deionized water (H₂O)

–

Deionized water (H₂O)

–